Abstract
The isolation of human coronavirus NL63 (HCoV-NL63) in The Netherlands raised questions about its contribution to respiratory illness. In this study, a total of 525 respiratory specimens, collected in Canada primarily during the winter months of 2001-2002, were tested for HCoV-NL63; 19 tested positive for HCoV-NL63, demonstrating virus activity during January-March 2002. Patients with HCoV-NL63 were 1 month-100 years old (median age, 37 years). The main clinical presentations were fever (15/19), sore throat (5/19), and cough (9/19), and 4 patients were hospitalized. These results provide evidence for the worldwide distribution of HCoV-NL63.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Canada / epidemiology
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Child
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Child, Preschool
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Coronavirus / classification*
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Coronavirus / genetics
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Coronavirus / isolation & purification*
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Coronavirus Infections / epidemiology
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Coronavirus Infections / virology*
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Cough / etiology
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DNA, Complementary / chemistry
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DNA, Complementary / isolation & purification
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DNA, Viral / chemistry
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DNA, Viral / isolation & purification
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Fever / etiology
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Humans
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Infant, Newborn
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Middle Aged
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Molecular Epidemiology
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Molecular Sequence Data
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Pharyngitis / etiology
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Phylogeny
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Respiratory Tract Infections / epidemiology
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Respiratory Tract Infections / virology*
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Ribonuclease P / genetics
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Sequence Analysis, DNA
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Viral Proteins / genetics
Substances
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DNA, Complementary
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DNA, Viral
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Viral Proteins
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Ribonuclease P
Associated data
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GENBANK/AY675541
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GENBANK/AY675542
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GENBANK/AY675543
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GENBANK/AY675544
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GENBANK/AY675545
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GENBANK/AY675546
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GENBANK/AY675547
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GENBANK/AY675548
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GENBANK/AY675549
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GENBANK/AY675550
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GENBANK/AY675551
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GENBANK/AY675552
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GENBANK/AY675553