Abstract
Fluorescent-labeled DNA probes were used to study 52 chronic lymphocytic leukemia (B-CLL) patients for (1) disease progression, (2) angiogenesis genes, (3) T-cell leukemia 1 gene (TCL1), (4) immunoglobulin heavy chain variable region (IGHv) and (5) chromosome 6q. Compared to stable disease, more patients with progressive disease had > or =2 anomalies and a high percentage of neoplastic nuclei. Anomalies of genes for basic fibroblast growth factor, interleukin 4, vascular endothelial growth factor or TCL1 were not detected. Deletions in IGHv occurred in 25% of patients and correlated with IGHv gene expression. Probes for 6q23 detected more deletions in 6q than probes for 6q21.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Chromosome Aberrations*
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DNA Probes*
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Disease Progression
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Female
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Fibroblast Growth Factor 2 / genetics
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Genes, Immunoglobulin
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Humans
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Immunoglobulin Variable Region / genetics
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In Situ Hybridization, Fluorescence
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Interleukin-4 / genetics
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Leukemia, Lymphocytic, Chronic, B-Cell / classification*
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Male
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Middle Aged
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Neovascularization, Pathologic / genetics
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Prognosis
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Proto-Oncogene Proteins / genetics
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Vascular Endothelial Growth Factor A / genetics
Substances
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DNA Probes
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Immunoglobulin Variable Region
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Proto-Oncogene Proteins
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TCL1A protein, human
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Vascular Endothelial Growth Factor A
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Fibroblast Growth Factor 2
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Interleukin-4