Genome sequence and attenuating mutations in West Nile virus isolate from Mexico

Emerg Infect Dis. 2004 Dec;10(12):2221-4. doi: 10.3201/eid1012.040647.

Abstract

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Female
  • Genome, Viral*
  • Mexico
  • Mice
  • Mutation
  • Virulence / genetics
  • West Nile virus / genetics*
  • West Nile virus / pathogenicity