Abstract
The effect of acute high-dose glucocorticoid therapy on memory function in patients with acute optic neuritis (n = 9) and multiple sclerosis (n = 21) was studied. All patients had reversible impairment of long-term memory functions, whereas measures of short-term memory, attentional functions, and alertness remained unaffected.
MeSH terms
-
Adolescent
-
Adult
-
Anti-Inflammatory Agents / administration & dosage
-
Anti-Inflammatory Agents / adverse effects*
-
Anti-Inflammatory Agents / therapeutic use
-
Attention / drug effects
-
Female
-
Hippocampus / drug effects
-
Hippocampus / physiopathology*
-
Humans
-
Male
-
Memory / drug effects*
-
Memory Disorders / chemically induced*
-
Memory Disorders / physiopathology
-
Memory, Short-Term / drug effects
-
Mental Recall / drug effects
-
Methylprednisolone / administration & dosage
-
Methylprednisolone / adverse effects*
-
Methylprednisolone / therapeutic use
-
Middle Aged
-
Multiple Sclerosis / drug therapy*
-
Multiple Sclerosis / psychology
-
Neuropsychological Tests
-
Optic Neuritis / drug therapy*
-
Optic Neuritis / psychology
-
Stress, Physiological / psychology
-
Verbal Learning / drug effects
Substances
-
Anti-Inflammatory Agents
-
Methylprednisolone