Abstract
To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Carbon Radioisotopes / pharmacokinetics
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Corpus Striatum / diagnostic imaging
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Corpus Striatum / metabolism*
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Dopamine Antagonists / pharmacokinetics
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Dystonia Musculorum Deformans / genetics*
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Female
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Heterozygote
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Humans
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Imaging, Three-Dimensional
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Male
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Middle Aged
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Molecular Chaperones / genetics*
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Positron-Emission Tomography
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Protein Binding
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Raclopride / pharmacokinetics
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Radiopharmaceuticals / pharmacokinetics
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Receptors, Dopamine D2 / deficiency*
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Receptors, Dopamine D2 / metabolism
Substances
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Carbon Radioisotopes
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Dopamine Antagonists
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Molecular Chaperones
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Radiopharmaceuticals
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Receptors, Dopamine D2
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TOR1A protein, human
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Raclopride