During very early pregnancy, especially in the presence of complications associated with ART such as multiple gestation and OHSS, measurement of maternal levels of inhibin A offers a non-invasive test that can aid the counseling and management of patients. In the second trimester, assessment of maternal inhibin A levels has been shown to improve sensitivity of the existing serum screening tests for aneuploid pregnancies and made prove clinically useful in the early detection of pregnancies susceptible to developing pre-eclampsia. Assessment of inhibin B appears to offer useful prognostic information about ovulatory function and predictive information about response to treatment with gonadotropins.