Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues

Rafael León; José Marco-Contelles; Antonio G García; Mercedes Villarroya

doi:10.1016/j.bmc.2004.11.020

Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues

Bioorg Med Chem. 2005 Feb 15;13(4):1167-75. doi: 10.1016/j.bmc.2004.11.020.

Authors

Rafael León¹, José Marco-Contelles, Antonio G García, Mercedes Villarroya

Affiliation

¹ Laboratorio de Radicales Libres (IQOG, CSIC), C/ Juan de la Cierva 3, 28006 Madrid, Spain.

PMID: 15670925
DOI: 10.1016/j.bmc.2004.11.020

Abstract

The synthesis and the biological evaluation (acetylcholinesterase inhibition activity and neuroprotection) of the new tacrine analogues 2-14 is described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cattle
Cholinesterase Inhibitors / chemical synthesis*
Cholinesterase Inhibitors / pharmacology*
Chromaffin Cells / drug effects
Neuroprotective Agents / chemical synthesis*
Neuroprotective Agents / pharmacology*
Spectrum Analysis
Structure-Activity Relationship
Tacrine / analogs & derivatives*
Tacrine / chemical synthesis*
Tacrine / pharmacology

Substances

Cholinesterase Inhibitors
Neuroprotective Agents
Tacrine