Photolithographic synthesis of cyclic peptide arrays using a differential deprotection strategy

Shuwei Li; Nishanth Marthandan; Dawn Bowerman; Harold R Garner; Thomas Kodadek

doi:10.1039/b415578e

Photolithographic synthesis of cyclic peptide arrays using a differential deprotection strategy

Chem Commun (Camb). 2005 Feb 7:(5):581-3. doi: 10.1039/b415578e. Epub 2005 Jan 5.

Authors

Shuwei Li¹, Nishanth Marthandan, Dawn Bowerman, Harold R Garner, Thomas Kodadek

Affiliation

¹ Department of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.

PMID: 15672142
DOI: 10.1039/b415578e

Abstract

We report here a strategy for the photolithographic synthesis of diverse, spatially addressable arrays of cyclic peptides which employs a differential deprotection strategy for the combinatorial addition of side chains to a pre-fabricated cyclic core.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Molecular Structure
Peptide Library*
Peptides, Cyclic / chemical synthesis*
Printing*
Protein Array Analysis / methods*
Time Factors
Ultraviolet Rays*

Substances

Peptide Library
Peptides, Cyclic