Anti-ribosomal-P antibodies in a Sjögren syndrome patient associated with lupus erythematosus

J Dermatol. 2004 Oct;31(10):811-4. doi: 10.1111/j.1346-8138.2004.tb00605.x.

Abstract

We describe a 36-year-old woman who had Sjögren syndrome with anti-ribosomal P antibodies and who developed erythema on her back and arms. The histological specimen showed lymphocytic infiltration around the sweat and salivary glands. Her serum reacted with ribosomal-P0 protein in immunoblotting with HeLa cell extract and P0 recombinant protein. Although autoantibodies to ribosomal-P proteins appear mainly in patients with systemic lupus erythematosus (SLE), a diagnosis of SLE in this patient could not be supported.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Autoantibodies / immunology*
  • Biomarkers / analysis
  • Biopsy, Needle
  • Female
  • Fluorescent Antibody Technique, Indirect
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Erythematosus, Systemic / pathology*
  • Prednisolone / therapeutic use
  • Protozoan Proteins
  • Ribosomal Proteins / immunology*
  • Risk Assessment
  • Severity of Illness Index
  • Sjogren's Syndrome / complications
  • Sjogren's Syndrome / drug therapy
  • Sjogren's Syndrome / immunology*
  • Sjogren's Syndrome / pathology*
  • Treatment Outcome

Substances

  • Autoantibodies
  • Biomarkers
  • L12E protein, Trypanosoma cruzi
  • Protozoan Proteins
  • Ribosomal Proteins
  • Prednisolone