New ways to skin a kap: mechanisms for controlling nuclear transport

C Patrick Lusk; Taras Makhnevych; Richard W Wozniak

doi:10.1139/o04-111

New ways to skin a kap: mechanisms for controlling nuclear transport

Biochem Cell Biol. 2004 Dec;82(6):618-25. doi: 10.1139/o04-111.

Authors

C Patrick Lusk¹, Taras Makhnevych, Richard W Wozniak

Affiliation

¹ Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.

PMID: 15674429
DOI: 10.1139/o04-111

Abstract

Transport between the nucleus and the cytoplasm occurs through large macromolecular assemblies called nuclear pore complexes (NPCs). The NPC is traditionally viewed as a passive structure whose primary role is to provide an interface for the soluble transport machinery, the karyopherins and their cargos, to move molecules between these compartments. Recent work has challenged this view of the NPC and provides support for a dynamic structure that can modify its architecture to actively regulate nuclear transport.

Publication types

Review

MeSH terms

Active Transport, Cell Nucleus*
Animals
Cell Nucleus / metabolism*
DNA-Binding Proteins / metabolism
Karyopherins / physiology
Models, Biological
Nuclear Pore Complex Proteins / physiology*
Saccharomyces cerevisiae Proteins / metabolism
Transcription Factors / metabolism
Tumor Suppressor Protein p53 / metabolism

Substances

DNA-Binding Proteins
Karyopherins
Nuclear Pore Complex Proteins
PHO4 protein, S cerevisiae
Saccharomyces cerevisiae Proteins
Transcription Factors
Tumor Suppressor Protein p53