Reductions in levels of bacterial superantigens/cannabinoids by plasma exchange in a patient with severe toxic shock syndrome

Anaesth Intensive Care. 2004 Aug;32(4):588-91. doi: 10.1177/0310057X0403200420.

Abstract

Toxic shock syndrome is a rare but potentially fatal toxin-mediated febrile illness. We report a case of toxic shock syndrome complicated by life-threatening organ dysfunction with high toxin-1 and staphylococcus enterotoxin type A levels that were successfully reduced by early introduction of plasma exchanges. The report shows the time course of the concentrations of anandamide and 2-arachidonyl glyceride and confirms that early introduction of plasma exchange can result in a rapid reduction of circulating toxins and mediators in the treatment of life-threatening multiple organ dysfunction.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Arachidonic Acids / blood
  • Bacterial Toxins / blood
  • Cannabinoid Receptor Modulators / blood*
  • Diglycerides / blood
  • Endocannabinoids
  • Enterotoxins / blood
  • Humans
  • Male
  • Plasma Exchange*
  • Polyunsaturated Alkamides
  • Shock, Septic / blood
  • Shock, Septic / microbiology
  • Shock, Septic / therapy*
  • Staphylococcal Infections / blood
  • Staphylococcal Infections / therapy
  • Staphylococcus aureus / immunology
  • Superantigens / blood*

Substances

  • Arachidonic Acids
  • Bacterial Toxins
  • Cannabinoid Receptor Modulators
  • Diglycerides
  • Endocannabinoids
  • Enterotoxins
  • Polyunsaturated Alkamides
  • Superantigens
  • enterotoxin F, Staphylococcal
  • enterotoxin A, Staphylococcal
  • diarachidonyl diglyceride
  • anandamide