Case report of 40 year old female, admitted in emergency because signs and symptoms of upper digestive tract bleeding. Reappearance of bleeding, during haemodynamic compensation and dramatic installation of a haemorrhagic shock determines the surgical intervention for haemostasis. During surgery we discovered a duodenal ulcer with hypertrophic vessels, penetrating the gallbladder, that in its clinical course eroded the cystic artery. We performed bipolar cholecystectomy; removed the duodenal ulcer with anterior pilorectomy, Burlui antro-duodenostomy with a favorable postoperative course.