[Aurora kinases and cancer]

Gan To Kagaku Ryoho. 2005 Jan;32(1):1-5.
[Article in Japanese]

Abstract

Aurora kinases are highly conserved in eukaryotes and involved in many processes during cell division. Three Aurora kinases have been identified in humans and designated as Aurora-A, -B, and -C. Aurora A regulates centrosome function during M phase through its interactions with various cell cycle regulators including TACC, chTOG, Ajuba, BRCA1, LATS2, and p53. Aurora-B localizes at the kinetochore from G2 to metaphase, and relocates to the midbody after anaphase. Aurora-B plays roles in spindle dynamics, chromosome condensation, and cytokinesis by interacting with many proteins such as INCENP, Survivin, CENP-A, MgcRacGAP, and intermediate filaments. Overexpression of both Aurora-A and -B proteins is frequently observed in various human cancer tissues, and a common coding region polymorphism in aurora-A affects the risk of breast or esophageal cancer. Ectopic overexpression of Aurora-A or -B protein leads to aneuploid cells. The cells overexpressing active Aurora A or wildtype Aurora-B are tumorigenic in nude mice.

Publication types

  • Review

MeSH terms

  • Animals
  • Aurora Kinase A
  • Aurora Kinase B
  • Aurora Kinases
  • BRCA1 Protein / genetics
  • Carrier Proteins / genetics
  • Cell Cycle / genetics
  • Cell Division / genetics
  • Fetal Proteins / genetics
  • Humans
  • Inhibitor of Apoptosis Proteins
  • Mice
  • Mice, Nude
  • Microtubule-Associated Proteins / genetics
  • Mutation
  • Neoplasm Proteins
  • Neoplasms / enzymology
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Nuclear Proteins / genetics
  • Protein Serine-Threonine Kinases / genetics*
  • Protein Serine-Threonine Kinases / metabolism*
  • Survivin
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Proteins / genetics

Substances

  • BIRC5 protein, human
  • BRCA1 Protein
  • Carrier Proteins
  • Fetal Proteins
  • Inhibitor of Apoptosis Proteins
  • Microtubule-Associated Proteins
  • Neoplasm Proteins
  • Nuclear Proteins
  • Survivin
  • TACC1 protein, human
  • TACC2 protein, human
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • LATS2 protein, human
  • AURKB protein, human
  • Aurka protein, mouse
  • Aurkb protein, mouse
  • Aurora Kinase A
  • Aurora Kinase B
  • Aurora Kinases
  • Protein Serine-Threonine Kinases