Physically handicapped farm operators and agricultural workers face barriers which make the completion of many essential farm-related tasks difficult or even impossible. These barriers are especially burdensome with respect to the operation and maintenance of agricultural equipment. This paper reports on work being done at Purdue University to assist handicapped farmers and agricultural workers who wish to continue working in spite of their disabilities. The nature of physical handicaps and proportion of farmers affected by these handicaps is discussed. Potential health and safety risks that these operators are exposed to when operating agricultural equipment are addressed. In addition, a brief overview of the Purdue project and recent activities is provided.