Antagonizing Wnt and FGF receptors: an enemy from within (the ER)

Xi He

doi:10.1016/j.cell.2005.01.006

Antagonizing Wnt and FGF receptors: an enemy from within (the ER)

Cell. 2005 Jan 28;120(2):156-8. doi: 10.1016/j.cell.2005.01.006.

Author

Xi He¹

Affiliation

¹ Division of Neuroscience, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

PMID: 15680320
DOI: 10.1016/j.cell.2005.01.006

Abstract

In this issue of Cell, Yamamoto et al. (2005) describe a novel molecule, Shisa, which functions in the endoplastic reticulum (ER) to prevent maturation of Frizzled (Fz) serpentine receptors and fibroblast growth factor receptor (FGFR). Shisa thus antagonizes Wnt and FGF signaling cell-autonomously, thereby promoting anterior patterning in Xenopus.

Publication types

Comment

MeSH terms

Animals
Embryo, Nonmammalian / metabolism
Endoplasmic Reticulum / metabolism*
Head / embryology
Intercellular Signaling Peptides and Proteins / metabolism*
Low Density Lipoprotein Receptor-Related Protein-6
Membrane Proteins / metabolism*
Receptors, Fibroblast Growth Factor / metabolism*
Receptors, LDL / metabolism
Signal Transduction / physiology*
Wnt Proteins
Xenopus / embryology
Xenopus / metabolism
Xenopus Proteins / metabolism

Substances

Intercellular Signaling Peptides and Proteins
Low Density Lipoprotein Receptor-Related Protein-6
Membrane Proteins
Receptors, Fibroblast Growth Factor
Receptors, LDL
Wnt Proteins
Xenopus Proteins