Abstract
We report a fucose alpha(1-2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucalpha(1-2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucalpha(1-2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Biotin / chemistry
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Disaccharides / metabolism
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Epitopes
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Fucose / metabolism
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Fucose / physiology*
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Galactose / metabolism
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Galactose / physiology*
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Hippocampus / cytology
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Humans
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Lectins / metabolism
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Lectins / pharmacology
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Neurites / drug effects
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Neurites / metabolism
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Neurites / physiology
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Neurons / cytology*
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Neurons / drug effects
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Neurons / metabolism
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Receptors, Mitogen / metabolism
Substances
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Disaccharides
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Epitopes
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Lectins
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Receptors, Mitogen
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Fucose
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Biotin
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Galactose