Cinchona alkaloid/sulfinyl chloride combinations: enantioselective sulfinylating agents of alcohols

J Am Chem Soc. 2005 Feb 9;127(5):1374-5. doi: 10.1021/ja0430189.

Abstract

We report a novel approach to asymmetric sulfinylation reactions based on a cinchona alkaloid/sulfinyl chloride combination that acts as the first asymmetric sulfinylating agents of achiral alcohols. Both enantiomers of arenesulfinates are obtained with up to 99% ee. The significantly high enantioselectivity observed in this case could be explained by dynamic kinetic resolution.

MeSH terms

  • Alcohols / chemistry*
  • Cinchona Alkaloids / chemistry*
  • Stereoisomerism
  • Sulfinic Acids / chemical synthesis*
  • Sulfinic Acids / chemistry

Substances

  • Alcohols
  • Cinchona Alkaloids
  • Sulfinic Acids