Chlorella virus PBCV-1 replication is not affected by cytoskeletal disruptors

Intervirology. 1992;33(2):116-20. doi: 10.1159/000150240.

Abstract

The majority, if not the entire life cycle, of the large dsDNA-containing algal virus PBCV-1 occurs in localized regions in the cytoplasm. Thirteen drugs that disrupt the cytoskeleton had no effect on PBCV-1 replication at concentrations which inhibited host growth. Therefore, host cytoskeletal elements do not appear to be important in PBCV-1 morphogenesis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chlorella* / drug effects
  • Chlorella* / ultrastructure
  • Cytoskeleton / drug effects*
  • DNA Viruses / drug effects*
  • DNA Viruses / physiology
  • Virus Replication / drug effects*