Primary B-cell lymphoma with histologic features of a T-cell neoplasm

J Am Acad Dermatol. 1992 Feb;26(2 Pt 2):288-92. doi: 10.1016/0190-9622(92)70036-f.

Abstract

A 58-year-old white man had dermatomyositis and primary cutaneous B-cell lymphoma. The cutaneous lymphoma was evidenced by a noduloulcerative disease of the lower extremities. Histologic results resembled a T-cell process with a diffuse, superficial infiltrate composed of small- and medium-sized lymphocytes with angioinvasion and epidermotropism. The infiltrate extended into the deep dermis and panniculus with scattered large lymphocytes and necrosis. With the help of gene-rearrangement analysis and immunophenotyping, the true B-cell lineage was discovered. The importance of gene-rearrangement analysis and immunophenotyping in the diagnosis of cutaneous lymphoma is emphasized.

Publication types

  • Case Reports

MeSH terms

  • Blotting, Southern
  • Dermatomyositis / complications
  • Diagnosis, Differential
  • Humans
  • Immunophenotyping
  • Leg / pathology
  • Lymphoma, B-Cell / complications
  • Lymphoma, B-Cell / pathology*
  • Lymphoma, T-Cell, Peripheral / pathology*
  • Male
  • Middle Aged
  • Skin Neoplasms / complications
  • Skin Neoplasms / pathology*