Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells

Chem Commun (Camb). 2005 Feb 21:(7):845-7. doi: 10.1039/b417206j. Epub 2005 Jan 21.

Abstract

The uptake of zinc bis(thiosemicarbazone) complexes in human cancer cells has been studied by fluorescence microscopy and the cellular distribution established, including the degree of uptake in the nucleus.

MeSH terms

  • Cell Line, Tumor
  • Humans
  • Microscopy, Fluorescence / methods
  • Models, Molecular
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacokinetics*
  • Sensitivity and Specificity
  • Structure-Activity Relationship
  • Thiosemicarbazones / chemistry
  • Thiosemicarbazones / pharmacokinetics*
  • Tissue Distribution
  • Zinc / chemistry*

Substances

  • Organometallic Compounds
  • Thiosemicarbazones
  • Zinc