[Hereditary gastrointestinal neoplasias]

Z Gastroenterol. 2005 Feb;43(2):219-25. doi: 10.1055/s-2004-813928.
[Article in German]

Abstract

Hereditary gastrointestinal tumors account for approximately 5 % of the overall gastrointestinal cancer burden. The identification of underlying gene mutations opened up a new dimension regarding prediction and prevention of these hereditary tumors. In this review the current knowledge of epidemiology, clinical findings, pathology and genetic background, surveillance and treatment options of familial adenomatous polyposis (FAP), hereditary non-polyposis colorectal cancer syndrome (HNPCC), hereditary diffuse gastric cancer (HDGC) and familial pancreatic cancer (FPC) are described and discussed.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Adenomatous Polyposis Coli / diagnosis
  • Adenomatous Polyposis Coli / genetics*
  • Adenomatous Polyposis Coli / pathology
  • Adenomatous Polyposis Coli / therapy
  • Colon / pathology
  • Colonic Neoplasms / diagnosis
  • Colonic Neoplasms / genetics*
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / therapy
  • Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics*
  • Colorectal Neoplasms, Hereditary Nonpolyposis / pathology
  • Colorectal Neoplasms, Hereditary Nonpolyposis / therapy
  • DNA Mutational Analysis
  • Gastric Mucosa / pathology
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Intestinal Mucosa / pathology
  • Pancreas / pathology
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / therapy
  • Pedigree
  • Stomach / pathology
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / therapy