Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma

Nat Prod Res. 2005 Apr;19(3):283-6. doi: 10.1080/14786410410001714669.

Abstract

Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigemma, were tested for anti-inflammatory activities. Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / pharmacology*
  • Lauraceae / chemistry*
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*
  • Superoxides / analysis

Substances

  • Anti-Inflammatory Agents
  • Sesquiterpenes
  • Superoxides