Abstract
Novel mutual pro-drugs in which 2',3'-dideoxyinosine anti-HIV (human immunodeficiency virus) drug and 3-octadecyloxy-propane-1,2-diol anti-inflammatory drug were attached to the same molecule via different biodegradable linkages, were synthesized through two-step enzymatic transesterification by a commercial lipase in acetone.
MeSH terms
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Acetone
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / chemistry
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Anti-Inflammatory Agents / chemical synthesis
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Anti-Inflammatory Agents / chemistry
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Biochemistry / methods*
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Didanosine / chemical synthesis*
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Didanosine / chemistry
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Enzymes, Immobilized / chemistry
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Enzymes, Immobilized / metabolism
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Esterification
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Glyceryl Ethers / chemical synthesis*
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Glyceryl Ethers / chemistry
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Lipase / chemistry
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Lipase / metabolism
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Prodrugs / chemical synthesis*
Substances
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Anti-HIV Agents
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Anti-Inflammatory Agents
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Enzymes, Immobilized
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Glyceryl Ethers
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Prodrugs
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Acetone
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batyl alcohol
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Lipase
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Didanosine