Tetramethyl thiourea/Co2(CO)8-catalyzed Pauson-Khand reaction under balloon pressure of CO

Yefeng Tang; Lujiang Deng; Yandong Zhang; Guangbin Dong; Jiahua Chen; Zhen Yang

doi:10.1021/ol047651a

Tetramethyl thiourea/Co2(CO)8-catalyzed Pauson-Khand reaction under balloon pressure of CO

Org Lett. 2005 Feb 17;7(4):593-5. doi: 10.1021/ol047651a.

Authors

Yefeng Tang¹, Lujiang Deng, Yandong Zhang, Guangbin Dong, Jiahua Chen, Zhen Yang

Affiliation

¹ Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry, and Laboratory of Chemical Genetics, ShenZhen Graduate School, Peking University, Beijing 100871, China.

PMID: 15704902
DOI: 10.1021/ol047651a

Abstract

A Pauson-Khand type of conversion of enynes to bicyclic cyclopentenones employing the commercially available Co2(CO)8 and tetramethylthiourea (TMTU) as catalysts is described. This method allows a variety of enynes with diverse functional groups to be cyclized into cyclopentenones of interest. [reaction: see text]

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbon Monoxide*
Catalysis
Cyclization
Pressure
Thiourea / analogs & derivatives*
Thiourea / chemistry

Substances

Carbon Monoxide
Thiourea
tetramethylthiourea