Abstract
In 20 patients with myeloid malignancies and isolated trisomy 11 an internal tandem duplication of the MLL and FLT3 genes was observed in 41% and 31% of the cases, respectively; 80% of the FLT3+ cases showed MLL self-fusion. Concomitant presence of MLL and FLT3 anomalies could be relevant in determining the poor outcome of patients with acute myeloid leukemia with trisomy 11.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Chromosomes, Human, Pair 11*
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Gene Duplication*
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Gene Expression Regulation, Neoplastic*
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Histone-Lysine N-Methyltransferase
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Humans
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Karyotyping
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Leukemia, Myeloid / genetics*
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Middle Aged
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Myeloid-Lymphoid Leukemia Protein / genetics*
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Time Factors
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Trisomy*
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fms-Like Tyrosine Kinase 3 / genetics*
Substances
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KMT2A protein, human
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Myeloid-Lymphoid Leukemia Protein
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Histone-Lysine N-Methyltransferase
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FLT3 protein, human
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fms-Like Tyrosine Kinase 3