Fulminant hepatitis B associated with a specific insertion in the basal core promoter region of hepatitis B virus DNA after immunosuppressive treatment

René Gérolami; Mireille Henry; Patrick Borentain; Philippe Colson; Danièle Botta; Catherine Tamalet

doi:10.1086/427146

Fulminant hepatitis B associated with a specific insertion in the basal core promoter region of hepatitis B virus DNA after immunosuppressive treatment

Clin Infect Dis. 2005 Feb 15;40(4):e24-7. doi: 10.1086/427146. Epub 2005 Jan 21.

Authors

René Gérolami¹, Mireille Henry, Patrick Borentain, Philippe Colson, Danièle Botta, Catherine Tamalet

Affiliation

¹ Service de Gastro-entérologie et Hépatologie, Hôpital de la Conception, Marseille, France.

PMID: 15712066
DOI: 10.1086/427146

Abstract

We report a case of hepatitis B virus reactivation that occurred after immunosuppressive treatment in a hepatitis B surface antigen-negative patient with detectable antibodies to hepatitis B core antigen and hepatitis B surface antigen. Sequence analysis revealed an 11-bp insertion in the core promoter region of hepatitis virus DNA, creating a novel hepatocyte nuclear factor-1 binding site. This led to enhanced viral replication and fulminant hepatitis.

Publication types

Case Reports

MeSH terms

Female
Hepatitis B / drug therapy*
Hepatitis B / virology
Hepatitis B Antibodies / blood
Hepatitis B Core Antigens / genetics*
Hepatitis B Core Antigens / immunology
Hepatitis B Surface Antigens / immunology
Hepatitis B virus / genetics*
Hepatitis B virus / immunology
Hepatitis B virus / physiology
Humans
Immunosuppressive Agents / therapeutic use
Liver Failure, Acute / drug therapy*
Liver Failure, Acute / virology
Molecular Sequence Data
Mutation
Promoter Regions, Genetic / genetics*
Virus Activation

Substances

Hepatitis B Antibodies
Hepatitis B Core Antigens
Hepatitis B Surface Antigens
Immunosuppressive Agents

Associated data

GENBANK/AF479684