The purpose of this study is to describe our experience in the endovascular management of two cases of aortoenteric and aortoesophageal fistula that were unsuccessfully treated with an aortic stent graft because of recurrent infection. Although endovascular repair appears to be a promising therapeutic modality, in the presence of infection this technique should be considered on an individual basis. Failure of treatment should be expected in a significant number of cases during follow-up, particularly in patients with signs of sepsis. A review of the literature with positive and negative results has been included for a better understanding of this condition.