In slipped capital femoral epiphysis (SCFE), cannulated screw fixation is a standard procedure. The aim of this study was to investigate the feasibility of a fluoroscopy-supported navigation system for screw fixation in SCFE. Using a fluoroscopy-enhanced navigation system, a cannulated screw fixation was performed in seven hips of four patients. The navigation system showed a high feasibility in instrument visualization and implant placing. The mean x-ray time was 6.2 seconds. Initial experiences are very promising and show advantages of the fluoroscopy-supported navigation. Considerably reduced x-ray exposure for patients and surgeons is possible. In the future, further efforts will be necessary to develop navigation-specific instruments to enhance the precision of screw positioning.