Abstract
The rare t(9;11)(p22;p15) translocation is associated with adult acute myeloid leukemia (AML) with immature forms. We report a novel fusion of the NUP98 and LEDGF genes in a pediatric AML with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes exhibiting the same chromosomal rearrangement. Fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR (RT-PCR) studies identified the chimeric transcript product of in-frame fusion of NUP98 exon 8 to LEDGF exon 4.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Artificial Gene Fusion
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Child, Preschool
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Chromosome Mapping
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Chromosomes, Human, Pair 11*
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Chromosomes, Human, Pair 22*
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Female
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Humans
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In Situ Hybridization, Fluorescence
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Intercellular Signaling Peptides and Proteins / genetics*
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Karyotyping
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Leukemia, Myeloid, Acute / genetics*
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Nuclear Pore Complex Proteins / genetics*
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Reverse Transcriptase Polymerase Chain Reaction
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Translocation, Genetic*
Substances
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Intercellular Signaling Peptides and Proteins
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Nuclear Pore Complex Proteins
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Nup98 protein, human
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lens epithelium-derived growth factor