Model for DNA hairpin denaturation

Eur Phys J E Soft Matter. 2005 Mar;16(3):235-46. doi: 10.1140/epje/e2005-00026-9.

Abstract

We investigate the thermal denaturation of DNA hairpins using molecular dynamics simulations of a simple model describing the molecule at a scale of a nucleotide. The model allows us to analyze the different interacting features that determine how an hairpin opens, such as therole of the loop and the properties intrinsic to the stem.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Computer Simulation
  • DNA / chemistry*
  • DNA / ultrastructure*
  • Models, Chemical*
  • Models, Molecular*
  • Nucleic Acid Conformation
  • Nucleic Acid Denaturation*

Substances

  • DNA