2,4,6-Trisubstituted pyrimidine derivatives as pregnancy interceptive agents

Anu Agarwal; Brijesh Kumar; Purshottam K Mehrotra; Prem M S Chauhan

doi:10.1016/j.bmc.2005.01.020

2,4,6-Trisubstituted pyrimidine derivatives as pregnancy interceptive agents

Bioorg Med Chem. 2005 Mar 15;13(6):1893-9. doi: 10.1016/j.bmc.2005.01.020.

Authors

Anu Agarwal¹, Brijesh Kumar, Purshottam K Mehrotra, Prem M S Chauhan

Affiliation

¹ Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India.

PMID: 15727845
DOI: 10.1016/j.bmc.2005.01.020

Abstract

A series of 2,4,6-trisubstituted pyrimidine derivatives was synthesized and evaluated for their in vivo pregnancy interceptive activity in hamsters. Out of the 17 compounds synthesized three compounds showed 100% activity at a dose of 10mg/kg.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abortifacient Agents / chemical synthesis
Abortifacient Agents / chemistry*
Abortifacient Agents / pharmacology*
Animals
Cricetinae
Female
Molecular Structure
Pregnancy
Pyrimidines / chemical synthesis
Pyrimidines / chemistry*
Pyrimidines / pharmacology*
Structure-Activity Relationship

Substances

Abortifacient Agents
Pyrimidines
pyrimidine