Abstract
Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with their structural similarity to combretastatins and their heterocyclic analogues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bibenzyls / chemical synthesis
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Bibenzyls / chemistry*
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Bibenzyls / pharmacology*
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Cattle
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Ethylenes / chemistry*
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Inhibitory Concentration 50
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Molecular Structure
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Naphthalenes / chemistry*
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Stilbenes / chemical synthesis
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Stilbenes / chemistry*
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Stilbenes / pharmacology*
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Structure-Activity Relationship
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Tubulin / metabolism
Substances
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Bibenzyls
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Ethylenes
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Naphthalenes
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Stilbenes
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Tubulin
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naphthalene
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combretastatin
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ethylene