Abstract
The in vitro activity of six cathelicidin peptides against 25 strains of Chlamydia was investigated. SMAP-29 proved to be the most active peptide, reducing the inclusion numbers of all 10 strains of Chlamydia trachomatis tested by > or =50% at 10 microg/ml. This peptide was also active against C. pneumoniae and C. felis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimicrobial Cationic Peptides / pharmacology*
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Blood Proteins / pharmacology*
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Cathelicidins
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Chlamydia / drug effects*
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Chlamydia trachomatis / drug effects
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Chlamydophila pneumoniae / drug effects
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Peptides, Cyclic / pharmacology*
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Proteins / pharmacology*
Substances
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Antimicrobial Cationic Peptides
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BMAP-27
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BMAP-28
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Blood Proteins
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Cathelicidins
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Peptides, Cyclic
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Proteins
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SMAP29 protein, Ovis aries
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protegrin-1
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bactenecin