Abstract
The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-beta) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-beta during HCMV infection. IE86 also efficiently blocked the induction of IFN-beta following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-beta is not limited to HCMV infection, identifying IE2 as an IFN-beta antagonist.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cells, Cultured
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Cytomegalovirus / immunology
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Cytomegalovirus / physiology*
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Humans
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Immediate-Early Proteins / genetics
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Immediate-Early Proteins / physiology*
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Interferon-beta / antagonists & inhibitors*
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Interferon-beta / biosynthesis*
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Sendai virus / immunology
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Trans-Activators / genetics
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Trans-Activators / physiology*
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Virus Replication
Substances
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IE2 protein, Cytomegalovirus
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Immediate-Early Proteins
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Trans-Activators
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Interferon-beta