Abstract
Objective:
To observe the influence of chemotherapy on the switching of Th1/Th2 cytokines in stomach cancer patients.
Methods:
Th1/Th2 cytokine genes expressed by peripheral blood mononuclear cells of stomach cancer patients before and after chemotherapy were detected by RT-PCR.
Results:
The expression of Th2 cytokines was dominant in patients before chemotherapy, and the dominancy became less marked after chemotherapy.
Conclusion:
The immune deviation with Th2 predominance in stomach cancer patients has a tendency to become reversed after chemotherapy.
MeSH terms
-
Adenocarcinoma* / drug therapy
-
Adenocarcinoma* / immunology
-
Adenocarcinoma* / metabolism
-
Aged
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Female
-
Fluorouracil / administration & dosage
-
Humans
-
Interferon-gamma / metabolism
-
Interleukins / metabolism*
-
Leucovorin / administration & dosage
-
Male
-
Middle Aged
-
Organoplatinum Compounds / administration & dosage
-
Oxaliplatin
-
Stomach Neoplasms* / drug therapy
-
Stomach Neoplasms* / immunology
-
Stomach Neoplasms* / metabolism
-
Th1 Cells / metabolism
-
Th2 Cells / metabolism*
Substances
-
Interleukins
-
Organoplatinum Compounds
-
Oxaliplatin
-
Interferon-gamma
-
Leucovorin
-
Fluorouracil