New allosteric modulators of metabotropic glutamate receptor 5 (mGluR5) found by ligand-based virtual screening

Chembiochem. 2005 Apr;6(4):620-5. doi: 10.1002/cbic.200400332.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allosteric Site*
  • Animals
  • Binding, Competitive / drug effects
  • Cell Membrane / metabolism
  • Databases, Factual
  • Drug Evaluation, Preclinical / methods
  • Excitatory Amino Acid Antagonists / chemistry*
  • Excitatory Amino Acid Antagonists / metabolism
  • Excitatory Amino Acid Antagonists / pharmacology
  • Ligands
  • Male
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Neural Networks, Computer
  • Prosencephalon / metabolism
  • Pyridines / chemistry
  • Pyridines / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors*
  • Receptors, Metabotropic Glutamate / metabolism
  • Solubility

Substances

  • Excitatory Amino Acid Antagonists
  • Grm5 protein, rat
  • Ligands
  • Pyridines
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor type 1
  • 6-methyl-2-(phenylethynyl)pyridine