Homing in on intracellular Abeta?

Neuron. 2005 Mar 3;45(5):639-42. doi: 10.1016/j.neuron.2005.02.013.

Abstract

In this issue of Neuron, a study by Billings et al. points to intracellular Abeta as a possible cause of neuronal dysfunction. In a mouse model of Alzheimer's disease, Billings et al. link appearance of intraneuronal Abeta to cognitive impairments and then show that "clearance" of intraneuronal Abeta by anti-Abeta antibodies restores cognitive deficits.

Publication types

  • Comment
  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / analysis
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Humans
  • Intracellular Fluid / chemistry
  • Intracellular Fluid / metabolism*

Substances

  • Amyloid beta-Peptides