Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)

Alex F De Vos; Debby A J van Riel; Marjan van Meurs; Herbert P M Brok; Louis Boon; Rogier Q Hintzen; Eric Claassen; Bert A 't Hart; Jon D Laman

doi:10.1016/j.jneuroim.2004.12.002

Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)

J Neuroimmunol. 2005 Apr;161(1-2):29-39. doi: 10.1016/j.jneuroim.2004.12.002. Epub 2005 Jan 25.

Authors

Alex F De Vos¹, Debby A J van Riel, Marjan van Meurs, Herbert P M Brok, Louis Boon, Rogier Q Hintzen, Eric Claassen, Bert A 't Hart, Jon D Laman

Affiliation

¹ Department of Immunology, Erasmus MC, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

PMID: 15748941
DOI: 10.1016/j.jneuroim.2004.12.002

Abstract

Recent data suggest that the spleen is a crucial component of the immune system in the development of experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys. Using immunohistochemistry, we investigated changes in the distribution of leukocytes in the spleen associated with clinical symptoms of EAE. Animals without EAE displayed well-developed T- and B-cell areas, germinal centers and red pulp. In contrast, a marked depletion of periarteriolar T cells with preservation of other elements was found in animals with clinical EAE. These findings suggest that immune responses within the spleen are impaired during a paralysing inflammatory process in the central nervous system.

Publication types

Comparative Study

MeSH terms

Acid Phosphatase / metabolism
Animals
Antigens, CD / classification
Antigens, CD / metabolism
Callithrix
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental / chemically induced
Encephalomyelitis, Autoimmune, Experimental / metabolism*
Encephalomyelitis, Autoimmune, Experimental / pathology*
Female
Humans
Immunoglobulin G / metabolism
Immunoglobulin M / metabolism
Immunohistochemistry / methods
Lymphocyte Activation / drug effects
Lymphocyte Activation / physiology
Lymphocyte Depletion*
Lymphocytes / classification
Lymphocytes / metabolism*
Lymphocytes / pathology
Lymphocytes / ultrastructure
Macrophages / metabolism
Macrophages / pathology
Male
Membrane Glycoproteins / metabolism
Microscopy, Electron, Transmission / methods
Myelin Sheath
Nuclear Proteins / metabolism
Plasma Cells / drug effects
Plasma Cells / metabolism
Plasma Cells / pathology
Plasma Cells / ultrastructure
Receptors, Immunologic / metabolism
Sialic Acid Binding Ig-like Lectin 1
Spleen / metabolism*
Spleen / pathology
Spleen / ultrastructure
T-Lymphocytes / immunology*
T-Lymphocytes / ultrastructure
T-Lymphocytes / virology
ran GTP-Binding Protein / metabolism

Substances

Antigens, CD
Immunoglobulin G
Immunoglobulin M
Membrane Glycoproteins
Nuclear Proteins
Receptors, Immunologic
SIGLEC1 protein, human
Sialic Acid Binding Ig-like Lectin 1
Acid Phosphatase
ran GTP-Binding Protein