Effect of halving the daily dose of triptorelin at the start of ovarian stimulation on hormone serum levels and the outcome of in vitro fertilization

Francisco Fábregues; Joana Peñarrubia; Montserrat Creus; Roser Casamitjana; Juan A Vanrell; Juan Balasch

doi:10.1016/j.fertnstert.2004.10.032

Effect of halving the daily dose of triptorelin at the start of ovarian stimulation on hormone serum levels and the outcome of in vitro fertilization

Fertil Steril. 2005 Mar;83(3):785-8. doi: 10.1016/j.fertnstert.2004.10.032.

Authors

Francisco Fábregues¹, Joana Peñarrubia, Montserrat Creus, Roser Casamitjana, Juan A Vanrell, Juan Balasch

Affiliation

¹ Institut Clínic of Gynecology, Obstetrics and Neonatology, Hospital Clínic, Faculty of Medicine-University of Barcelona, Barcelona, Spain.

PMID: 15749520
DOI: 10.1016/j.fertnstert.2004.10.032

Abstract

Halving the standard daily dose of triptorelin at the start of ovarian stimulation in down-regulated women stimulated with recombinant FSH is enough for pituitary suppression and was associated with higher LH serum concentrations in the follicular phase. However, this did not translate into higher serum concentrations of androstenedione and E2 and had no significant effect on ovarian response and the outcome of IVF/intracytoplasmic sperm injection.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Androstenedione / blood
Estradiol / blood
Female
Fertilization in Vitro*
Humans
Luteinizing Hormone / blood
Luteolytic Agents / administration & dosage*
Ovulation Induction / methods*
Pregnancy
Pregnancy Outcome*
Prospective Studies
Sperm Injections, Intracytoplasmic
Triptorelin Pamoate / administration & dosage*

Substances

Luteolytic Agents
Triptorelin Pamoate
Androstenedione
Estradiol
Luteinizing Hormone