Abstract
A prospective study was performed to determine the effects of the angiostatic compounds anti-hVEGF antibody, TNP-470, endostatin, and anginex on the vascularization and on endometriosis-like lesion formation in the chicken chorioallantoic membrane model. Endometriosis-like lesion formation was significantly impaired after treatment with angiostatic agents, which was associated with decreased vessel densities in the surrounding chorioallantoic membrane and more necrosis in the endometriosis-like lesions.
MeSH terms
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Antibodies / pharmacology
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Chick Embryo
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Chickens
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Chorioallantoic Membrane / blood supply*
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Chorioallantoic Membrane / pathology
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Cyclohexanes
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Endometriosis / prevention & control*
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Endostatins / pharmacology
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Female
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Neovascularization, Pathologic / drug therapy*
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Neovascularization, Pathologic / prevention & control
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O-(Chloroacetylcarbamoyl)fumagillol
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Sesquiterpenes / pharmacology*
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Vascular Endothelial Growth Factor A / immunology
Substances
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Angiogenesis Inhibitors
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Antibodies
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Cyclohexanes
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Endostatins
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Sesquiterpenes
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Vascular Endothelial Growth Factor A
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O-(Chloroacetylcarbamoyl)fumagillol