Abstract
Of 162 multidrug-resistant Mycobacterium tuberculosis isolates from Taiwan, 60.5% were found to belong to the Beijing family on the basis of spoligotyping results. IS6110 restriction fragment length polymorphism fingerprinting showed genetic diversity among the multidrug-resistant isolates. Furthermore, 90.1% of the multidrug-resistant isolates had mutations in the rpoB gene, and 11 novel alleles were recognized.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles*
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Base Sequence
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DNA-Directed RNA Polymerases / genetics*
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Drug Resistance, Multiple, Bacterial*
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Genetic Variation
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Genotype
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Molecular Sequence Data
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Mycobacterium tuberculosis / classification
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / genetics*
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Polymorphism, Restriction Fragment Length
Substances
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DNA-Directed RNA Polymerases
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RNA polymerase beta subunit
Associated data
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GENBANK/AY823310
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GENBANK/AY823311
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GENBANK/AY823312
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GENBANK/AY823313
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GENBANK/AY823314
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GENBANK/AY823315
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GENBANK/AY823316
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GENBANK/AY823317
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GENBANK/AY823318