Hypereosinophilic dermatitis-like erythema annulare centrifugum in a patient with chronic lymphocytic leukaemia

J Eur Acad Dermatol Venereol. 2005 Mar;19(2):228-31. doi: 10.1111/j.1468-3083.2005.01052.x.

Abstract

A 65-year-old male presented with a history of disseminated erythema annulare centrifugum lesions and a high peripheral blood eosinophilia (55%). Histopathology of a lesion revealed a superficial and deep perivascular and interstitial inflammatory eosinophilic infiltrate. The bone marrow aspirate showed a heavy eosinophilic infiltrate. There was no evidence of any other systemic involvement except for bone marrow eosinophilia. The patient had a 6-year history of chronic lymphocytic leukaemia. The disease is in complete remission for the last 3 years. The clinical and histopathological findings in the reported patient correspond to the diagnosis of hypereosinophilic dermatitis. Topical treatment with corticosteroid creams was successful. The cutaneous lesions gradually resolved in 8 weeks, within 7 months the peripheral blood eosinophilia slowly declined from 55% to 7%.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bone Marrow / pathology
  • Dermatitis / complications*
  • Dermatitis / pathology
  • Eosinophils / pathology
  • Erythema / complications*
  • Erythema / pathology
  • Humans
  • Hypereosinophilic Syndrome / complications*
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications*
  • Male
  • Skin / pathology*