Abstract
Rasmussen encephalitis (RE) is regarded as a unihemispheric disease. Serial three-dimensional MRIs of 18 patients under immunotherapy were analyzed volumetrically and planimetrically. Median volume loss was significantly higher in the affected than in the unaffected hemispheres (29.9 cm3/y vs 6.8 cm3/y). Correlation of the planimetrically and volumetrically assessed hemispheric ratios (HRs) was significant. The results support the concept of RE as a basically unilateral disease. Planimetric HR assessment is valid and time efficient.
MeSH terms
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Adolescent
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Adult
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Age of Onset
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Atrophy / diagnosis*
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Atrophy / etiology
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Atrophy / physiopathology
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Brain Damage, Chronic / diagnosis*
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Brain Damage, Chronic / etiology
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Brain Damage, Chronic / physiopathology
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Child
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Child, Preschool
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Disease Progression
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Encephalitis / diagnosis*
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Encephalitis / drug therapy
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Encephalitis / physiopathology
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Female
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Follow-Up Studies
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Functional Laterality / physiology*
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Humans
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Image Processing, Computer-Assisted / methods
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Image Processing, Computer-Assisted / standards
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Immunotherapy
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Infant
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Magnetic Resonance Imaging / methods*
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Magnetic Resonance Imaging / standards
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Male
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Predictive Value of Tests
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Regression Analysis
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Reproducibility of Results
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Telencephalon / drug effects
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Telencephalon / pathology*
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Telencephalon / physiopathology