Abstract
The subthalamic nucleus (STN) is a crucial node in the basal ganglia. Clinical success in targeting the STN for deep brain stimulation in Parkinson's disease patients has prompted increased interest in understanding STN biology. In this report, we discuss recent evidence for transcription factor mediated regulation of STN development. We also review STN developmental neurobiology and known patterns of gene expression in the developing and mature STN.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Brain Diseases / metabolism
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Gene Expression Regulation, Developmental / physiology*
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Gene Expression*
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Humans
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Neural Networks, Computer
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Neural Pathways / anatomy & histology
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Neural Pathways / physiology
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Neurons / physiology
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Subthalamic Nucleus / cytology
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Subthalamic Nucleus / growth & development
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Subthalamic Nucleus / metabolism*
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Transcription Factors* / genetics
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Transcription Factors* / metabolism