Abstract
Novel N-[[dialkylamino)ethoxy]benzyl]benzamide derivatives (II-1-51), derived from the structural modification of metoclopramide (I), were synthesized and examined for their pharmacological activities. Among them, N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide (II-34) which exhibited well balanced gastrointestinal prokinetic and antiemetic activities was selected as a new type of gastrointestinal prokinetic agent.
MeSH terms
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Amines / chemical synthesis*
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Animals
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Antiemetics / pharmacology
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Benzamides / chemical synthesis*
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Benzyl Compounds / chemical synthesis
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Benzyl Compounds / pharmacology
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Dogs
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Gastrointestinal Agents / chemical synthesis*
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Gastrointestinal Agents / pharmacology
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Gastrointestinal Transit / drug effects
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Guinea Pigs
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In Vitro Techniques
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Male
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Mice
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Mice, Inbred Strains
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
Substances
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Amines
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Antiemetics
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Benzamides
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Benzyl Compounds
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Gastrointestinal Agents