Asymmetric synthesis of novel tetrahydroquinoline derivatives with a sugar building block and their bioactivities

Hong-Min Liu; Feng-Wu Liu; Da-Peng Zou; Gui-Fu Dai

doi:10.1016/j.bmcl.2005.02.024

Asymmetric synthesis of novel tetrahydroquinoline derivatives with a sugar building block and their bioactivities

Bioorg Med Chem Lett. 2005 Apr 1;15(7):1821-4. doi: 10.1016/j.bmcl.2005.02.024.

Authors

Hong-Min Liu¹, Feng-Wu Liu, Da-Peng Zou, Gui-Fu Dai

Affiliation

¹ Department of Chemistry, Zhengzhou University, 75, Daxue Road, Zhengzhou 450052, PR China. [email protected]

PMID: 15780614
DOI: 10.1016/j.bmcl.2005.02.024

Abstract

Some novel spiro-tetrahydroquinolines were stereoselectively synthesized by using keto-sugar derived from sucrose as a building block in one pot under mild conditions. The in vitro immunobiological activity and cytotoxicity of these novel tetrahydroquinolines were investigated. The results implied that these spiro-compounds have obvious bioactivity and may be structurally modified to improve bioactivity further.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Carbohydrates / chemistry*
Cell Line, Tumor
Cyclization
Humans
Quinolines / chemical synthesis*
Quinolines / pharmacology
Stereoisomerism
Structure-Activity Relationship

Substances

Antineoplastic Agents
Carbohydrates
Quinolines