Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives as potential anxiolytic agents. Part 2: substitutions by methyl groups on the tetrahydrofuran ring

Farmaco. 2005 Mar;60(3):241-8. doi: 10.1016/j.farmac.2004.12.008.

Abstract

New synthesis approaches that have led to a series of novel tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives are described. A systematic synthetic approach for the introduction of small carbon substituents (methyl groups) around the tetrahydrofuran moiety of tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives is reported. Preliminary pharmacological data of the newly synthesised compounds are also communicated.

MeSH terms

  • Anti-Anxiety Agents / chemical synthesis*
  • Anti-Anxiety Agents / pharmacology
  • Benzofurans / chemical synthesis*
  • Benzofurans / pharmacology
  • Binding Sites
  • Furans / chemistry*
  • Oxepins / chemical synthesis*
  • Oxepins / pharmacology
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Anti-Anxiety Agents
  • Benzofurans
  • Furans
  • Oxepins
  • tetrahydrofuran