Abstract
Two new sesquiterpenoid esters (1 and 2) were isolated from the extract of Blumea balsamifera, a tropical Compositae plant. Compound 2 proved to be weakly cytotoxic when tested against Jurkat human T-cell leukemia cells. Nine known flavonoids, of which two showed plasmin-inhibitory activity, were also isolated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Asteraceae / chemistry*
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Drug Screening Assays, Antitumor
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Fibrinolysin / antagonists & inhibitors*
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology
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Humans
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Inhibitory Concentration 50
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Jurkat Cells / drug effects
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Thailand
Substances
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Antineoplastic Agents, Phytogenic
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Flavonoids
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Sesquiterpenes
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Fibrinolysin