Synthesis of epothilones via a silicon-tethered RCM reaction

Tanja Gaich; Johann Mulzer

doi:10.1021/ol0500923

Synthesis of epothilones via a silicon-tethered RCM reaction

Org Lett. 2005 Mar 31;7(7):1311-3. doi: 10.1021/ol0500923.

Authors

Tanja Gaich¹, Johann Mulzer

Affiliation

¹ Institut für Organische Chemie, Universität Wien, Währingerstrasse 38, A-1090-Wien, Austria.

PMID: 15787494
DOI: 10.1021/ol0500923

Abstract

[reaction: see text] A short synthesis of epothilone B and D is reported. The key step for generating the C12-13-trisubstituted Z-double bond uses a ring-closing metathesis reaction of a disiloxane to form a nine-membered silicon-tethered ring.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cyclization
Epothilones / analysis
Epothilones / chemical synthesis*
Molecular Structure
Silicon / chemistry*

Substances

Epothilones
desoxyepothilone B
epothilone B
Silicon