Cyclic bisphosphonate therapy in osteogenesis imperfecta type V

J Paediatr Child Health. 2005 Mar;41(3):147-51. doi: 10.1111/j.1440-1754.2005.00567.x.

Abstract

The clinical and radiographic features and management of a young person with recently delineated Osteogenesis Imperfecta Type V is described. A female aged 9 years presented with a history of multiple fractures since 3 years of age and bilateral dislocation of the elbows from infancy. She was commenced on a low dose frequent regimen of cyclic intravenous pamidronate, which resulted in progressive improvement in bone density, reduced fracture frequency and remission of symptoms of osteoporosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use*
  • Child
  • Diphosphonates / therapeutic use*
  • Female
  • Humans
  • Osteogenesis Imperfecta / classification
  • Osteogenesis Imperfecta / diagnostic imaging
  • Osteogenesis Imperfecta / drug therapy*
  • Pamidronate
  • Radiography
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Diphosphonates
  • Pamidronate